Quality Assessment and Dissolution Profile Comparison Studies on Naproxen Tablets Available in Karachi

  • Fatima Qamar Jinnah University for Women, Karachi Pakistan.
  • Samina Alam Jinnah University for Women, Karachi Pakistan.
  • Safila Naveed Jinnah University for Women, Karachi Pakistan.
  • Huma Ali Jinnah University for Women, Karachi Pakistan.

Abstract

Objective: Naproxen is prescribed for the treatment of pain and inflammation, indicated for the conditions such as arthritis, spondylitis, ankylosing andtendinitis. The aim of this study is to compare six different brands of Naproxen Sodium.


Methodology: Quality control parameters: weight variation test, thickness testing,hardness test, friability, disintegration and dissolution test were carried.


Result: Result revealed that all the six brands comply within limits for hardness, weight variation, thickness, friability, disintegration test. Disintegration time for all brands was within 15 minutes complying with the USP commendation.


Conclusion: The present findings suggest that all the brands meet the specification for quality control analysis. All the brands were best fitted with weibull model at pH7.4.

Author Biographies

Fatima Qamar, Jinnah University for Women, Karachi Pakistan.

Faculty of Pharmacy

Samina Alam, Jinnah University for Women, Karachi Pakistan.

Faculty of Pharmacy

Safila Naveed, Jinnah University for Women, Karachi Pakistan.

Faculty of Pharmacy

Huma Ali, Jinnah University for Women, Karachi Pakistan.

Faculty of Pharmacy

Published
2017-07-07
How to Cite
QAMAR, Fatima et al. Quality Assessment and Dissolution Profile Comparison Studies on Naproxen Tablets Available in Karachi. RADS Journal of Pharmacy and Pharmaceutical Sciences, [S.l.], v. 5, n. 2, p. 32-35, july 2017. ISSN 2521-8484. Available at: <http://jpps.juw.edu.pk/index.php/jpps/article/view/132>. Date accessed: 25 nov. 2017.