Toxicity Study of Infidol Colic Drop and Sennalax Administered Orally in NMRI Mice

  • Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan
  • Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan
  • Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan
  • Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan
  • Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan
  • Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan
  • Hunan University of Chinese Medicine, Changsha, China
  • Government College University, Faisalabad, Pakistan
  • Government College University, Faisalabad, Pakistan
  • King Saud Bin Abdulaziz University of Health Sciences, Jeddah, Kingdom of Saudi Arabia
Keywords: Herbal drug, infidol colic drops, sennalax, toxicity

Abstract

Objective: The present study was aimed to investigate preclinical oral toxicity of Infidol colic drop and Sennalax product.
Methods: NMRI strains of mice were selected for this study. Animals were divided into two groups i.e. control and treatment group (n=5/sex). Mice were treated orally using gastric gavage with doses (1 or 5 g/kg) of test product i.e. Infidol colic drops and sennalax, for 14 days and observed daily.
Result: The present study demonstrated that the infidol colic drops and sennalax is potentially safe with doses of 1000 & 5000 mg/kg, as it does not cause any apparent morbidity and mortality in the animals.
Conclusion: The test drug (Infidol colic drop and sennalax) could be safe because it did not show any of the side effects or toxicity on experimental animals.

Author Biographies

, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

Research & Development

, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

Research & Development

, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

Research & Development

, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

Research & Development

, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

Research & Development

, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

Research & Development

, Hunan University of Chinese Medicine, Changsha, China

TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy / College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation

, Government College University, Faisalabad, Pakistan

Department of Eastern Medicine, Directorate of Medical Sciences

, Government College University, Faisalabad, Pakistan

Department of Eastern Medicine, Directorate of Medical Sciences

, King Saud Bin Abdulaziz University of Health Sciences, Jeddah, Kingdom of Saudi Arabia

Department of Basic Medical Sciences, College of Medicine

Published
2018-06-20
Section
Articles