Toxicity Study of Infidol Colic Drop and Sennalax Administered Orally in NMRI Mice

  • Khan Usmanghani Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan
  • Saira Bano Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan
  • Rabia Ali Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan
  • Naeem Akhtar Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan
  • Amna Qadeer Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan
  • Kashifa Khanum Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan
  • Muhammad Daniyal Hunan University of Chinese Medicine, Changsha, China
  • Muhammad Akram Government College University, Faisalabad, Pakistan
  • Sultan Ayaz Government College University, Faisalabad, Pakistan
  • Kanwal Ahmed King Saud Bin Abdulaziz University of Health Sciences, Jeddah, Kingdom of Saudi Arabia

Abstract

Objective: The present study was aimed to investigate preclinical oral toxicity of Infidol colic drop and Sennalax product.
Methods: NMRI strains of mice were selected for this study. Animals were divided into two groups i.e. control and treatment group (n=5/sex). Mice were treated orally using gastric gavage with doses (1 or 5 g/kg) of test product i.e. Infidol colic drops and sennalax, for 14 days and observed daily.
Result: The present study demonstrated that the infidol colic drops and sennalax is potentially safe with doses of 1000 & 5000 mg/kg, as it does not cause any apparent morbidity and mortality in the animals.
Conclusion: The test drug (Infidol colic drop and sennalax) could be safe because it did not show any of the side effects or toxicity on experimental animals.

Author Biographies

Khan Usmanghani, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

Research & Development

Saira Bano, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

Research & Development

Rabia Ali, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

Research & Development

Naeem Akhtar, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

Research & Development

Amna Qadeer, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

Research & Development

Kashifa Khanum, Herbion Pakistan (Pvt.) Limited, Karachi, Pakistan

Research & Development

Muhammad Daniyal, Hunan University of Chinese Medicine, Changsha, China

TCM and Ethnomedicine Innovation & Development Laboratory, School of Pharmacy / College of Biology, Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation

Muhammad Akram, Government College University, Faisalabad, Pakistan

Department of Eastern Medicine, Directorate of Medical Sciences

Sultan Ayaz, Government College University, Faisalabad, Pakistan

Department of Eastern Medicine, Directorate of Medical Sciences

Kanwal Ahmed, King Saud Bin Abdulaziz University of Health Sciences, Jeddah, Kingdom of Saudi Arabia

Department of Basic Medical Sciences, College of Medicine

Published
2018-06-20
How to Cite
USMANGHANI, Khan et al. Toxicity Study of Infidol Colic Drop and Sennalax Administered Orally in NMRI Mice. RADS Journal of Pharmacy and Pharmaceutical Sciences, [S.l.], v. 6, n. 2, p. 119-123, june 2018. ISSN 2521-8484. Available at: <http://jpps.juw.edu.pk/index.php/jpps/article/view/202>. Date accessed: 17 oct. 2018.
Section
Articles