Research paper Formulation and Evaluation of Sustained Release Matrix Tablets of Furosemide Using Different Polymers

Abstract

Objective: The aim of the present research study was to develop and evaluate sustained release matrix tablets of 100 mg furosemide using direct compression method.
Method: Eighteen formulations were prepared using different natural polymers including xanthan gum, bees wax, carnauba wax and synthetic polymers i.e. HPMC (K100M, K15M, and K4M). These all polymers were used in different proportion to control the released of the drug. All formulations were evaluated using micromeritics studies of powder blend and different physicochemical tests.
Results: All the physicochemical characters of the formulated tablets were within acceptable limits. The release pattern of the drug was observed over a period of 12 hours and determined the amount of drug by the UV-Visible spectroscopic method. Dissolution data showed that the formulated tablets with Xanthan gum and hydroxyl propyl methylcellulose (HPMC) provided sustained release of the drug up to 12 hrs. Most of the formulations containing these two polymers were followed zero-order kinetics, Korsmeyer-Peppas and Higuchi models.
Conclusion: Hence economically it may be suitable for the pharmaceutical industries to use this type of simple technologies for the development of advanced formulations. Therefore, we conclude that the objective of this study was to formulate a sustained release matrix dosage form of furosemide using different polymers and their different proportions have been achieved.