Protein Kinase Inhibitory Potential and Anti-Fungal Activities of Metal Complexes of Anti-Viral Drug Ribavirin

Samar Akhtar; Hamaad Ahmad; Hashaam Akhtar; Rehman Zafar; Wajeeha Waseem; Maryam Khan Sherwani

Samar Akhtar Yusra Institute of Pharmaceutical Sciences, Yusra Medical and Dental Collage, Zaraj Housing Society, Opposite DHA Phase 2 Gate III, Main G.T. Road, Islamabad, 44000, Pakistan
Hamaad Ahmad Yusra Institute of Pharmaceutical Sciences, Yusra Medical and Dental Collage, Zaraj Housing Society, Opposite DHA Phase 2 Gate III, Main G.T. Road, Islamabad, 44000, Pakistan
Hashaam Akhtar Yusra Institute of Pharmaceutical Sciences, Yusra Medical and Dental Collage, Zaraj Housing Society, Opposite DHA Phase 2 Gate III, Main G.T. Road, Islamabad, 44000, Pakistan
Rehman Zafar Yusra Institute of Pharmaceutical Sciences, Yusra Medical and Dental Collage, Zaraj Housing Society, Opposite DHA Phase 2 Gate III, Main G.T. Road, Islamabad, 44000, Pakistan
Wajeeha Waseem Riphah Institute of Pharmaceutical Sciences, G-7/4, Islamabad, 44000, Pakistan
Maryam Khan Sherwani Yusra Institute of Pharmaceutical Sciences, Yusra Medical and Dental Collage, Zaraj Housing Society, Opposite DHA Phase 2 Gate III, Main G.T. Road, Islamabad, 44000, Pakistan

Keywords: Ribavirin, trace metals, protein kinase inhibition

Abstract

Background: Ribavirin, a known antiviral drug, potentially recognised for a number of pathological conditions like hepatitis C, Lassa fever and Hanta virus infection. It predominantly works by inhibiting viral RNA synthesis that in turn stop viral multiplication. The best prosperous derivative of this drug is Taribavirin (3-carboxamidine derivative).

Objective: In this research, we aim to synthesize the metal complexes of already marketed drug ribavirin, because the complexation of such approved marketed drug will save time and currency that may spend in relation to clinical development of new drug molecule.

Method: Eleven derivatives (S-01-S-11) of ribavirin were synthesized in combination with di/tri organotin, Zn, Cu and Fe. Characterization was done through IR and H¹ NMR spectrophotometer and these compounds were analysed for in vitro biological activities including anti-microbial, anti-fungal and protein kinase inhibition assay.

Results: Research revealed that addition of trace metals to approved marketed drug have enhanced the biological properties of unbound drug.

Conclusion: Outcomes of this research clearly indicates the enhancement of biological activities of free drug through immersion of metals which could be further analysed for toxicity studies.