Pharmaceutical Analysis of Different Brands of Solifenacin Tablets Available in Pakistani Market

  • Hamdard University, Karachi, Pakistan
  • Hamdard University, Karachi, Pakistan
  • Hamdard University, Islamabad Campus, Pakistan
  • Dow University of Health Sciences, Karachi, Pakistan
  • Hamdard University, Karachi, Pakistan
  • Hamdard University, Karachi, Pakistan
  • Hamdard University, Karachi, Pakistan
  • Hamdard University, Islamabad Campus, Pakistan
Keywords: Solifenacin, pharmaceutical analysis, quality parameters, HPLC method

Abstract

Objective: The current study was designed to evaluate and compare the quality and physiochemical characteristics of three different most commonly used brands of Solifenacin (10 mg) tablets available in Karachi, Pakistan.
Methods: Both the official and non-official tests were applied for the assessment of physical tests, such as hardness, thickness, weight variation, friability, disintegration and chemical tests like dissolution profile and assay using already reported HPLC method. Model independent approach like similarity factor (f2) was also applied to compare the dissolution profile of generic drug products with reference (innovator).
Results: The results of physical and chemical test showed that that all brands of Solifenacin were within the specified limits. The amount of Solifenacin in all three brands was within the USP specification of not less than 80% at 45 minutes. Similarly, the value of f2 indicated that all the brands were found to be similar with reference (innovator).
Conclusion: This study will help physicians and pharmacists for the selection of most appropriate quality brand for the treatment of active urinary bladder and in-continence episodes of urination.

Author Biographies

, Hamdard University, Karachi, Pakistan

Department of Pharmaceutics, Faculty of Pharmacy

, Hamdard University, Karachi, Pakistan

Department of Pharmaceutics, Faculty of Pharmacy

, Hamdard University, Islamabad Campus, Pakistan

Hamdard Institutes of Pharmaceutical Sciences

, Dow University of Health Sciences, Karachi, Pakistan

Department of Pharmaceutics, Faculty of Pharmaceutical Sciences

, Hamdard University, Karachi, Pakistan

Department of Pharmaceutics, Faculty of Pharmacy

, Hamdard University, Karachi, Pakistan

Department of Pharmaceutics, Faculty of Pharmacy

, Hamdard University, Karachi, Pakistan

Department of Pharmaceutics, Faculty of Pharmacy

, Hamdard University, Islamabad Campus, Pakistan

Department of Pharmaceutics, Faculty of Pharmacy

Published
2018-06-20
Section
Articles