Pharmaceutical Analysis of Different Brands of Solifenacin Tablets Available in Pakistani Market

  • Muhammad Raza Hamdard University, Karachi, Pakistan
  • Syed Baqir S. Naqvi Hamdard University, Karachi, Pakistan
  • Muhammad Iqbal Nasiri Hamdard University, Islamabad Campus, Pakistan
  • Tariq Ali Dow University of Health Sciences, Karachi, Pakistan
  • Kamran Zaheer Hamdard University, Karachi, Pakistan
  • Ali Saleem Hamdard University, Karachi, Pakistan
  • Humera Sarwar Hamdard University, Karachi, Pakistan
  • Muhmmad Azeem Hamdard University, Islamabad Campus, Pakistan

Abstract

Objective: The current study was designed to evaluate and compare the quality and physiochemical characteristics of three different most commonly used brands of Solifenacin (10 mg) tablets available in Karachi, Pakistan.
Methods: Both the official and non-official tests were applied for the assessment of physical tests, such as hardness, thickness, weight variation, friability, disintegration and chemical tests like dissolution profile and assay using already reported HPLC method. Model independent approach like similarity factor (f2) was also applied to compare the dissolution profile of generic drug products with reference (innovator).
Results: The results of physical and chemical test showed that that all brands of Solifenacin were within the specified limits. The amount of Solifenacin in all three brands was within the USP specification of not less than 80% at 45 minutes. Similarly, the value of f2 indicated that all the brands were found to be similar with reference (innovator).
Conclusion: This study will help physicians and pharmacists for the selection of most appropriate quality brand for the treatment of active urinary bladder and in-continence episodes of urination.

Author Biographies

Muhammad Raza, Hamdard University, Karachi, Pakistan

Department of Pharmaceutics, Faculty of Pharmacy

Syed Baqir S. Naqvi, Hamdard University, Karachi, Pakistan

Department of Pharmaceutics, Faculty of Pharmacy

Muhammad Iqbal Nasiri, Hamdard University, Islamabad Campus, Pakistan

Hamdard Institutes of Pharmaceutical Sciences

Tariq Ali, Dow University of Health Sciences, Karachi, Pakistan

Department of Pharmaceutics, Faculty of Pharmaceutical Sciences

Kamran Zaheer, Hamdard University, Karachi, Pakistan

Department of Pharmaceutics, Faculty of Pharmacy

Ali Saleem, Hamdard University, Karachi, Pakistan

Department of Pharmaceutics, Faculty of Pharmacy

Humera Sarwar, Hamdard University, Karachi, Pakistan

Department of Pharmaceutics, Faculty of Pharmacy

Muhmmad Azeem, Hamdard University, Islamabad Campus, Pakistan

Department of Pharmaceutics, Faculty of Pharmacy

Published
2018-06-20
How to Cite
RAZA, Muhammad et al. Pharmaceutical Analysis of Different Brands of Solifenacin Tablets Available in Pakistani Market. RADS Journal of Pharmacy and Pharmaceutical Sciences, [S.l.], v. 6, n. 2, p. 152-156, june 2018. ISSN 2521-8484. Available at: <http://jpps.juw.edu.pk/index.php/jpps/article/view/246>. Date accessed: 17 oct. 2018.
Section
Articles