Linezolid Study on Isolates of Staphylococcus aureus and Escherichia coli Through Disc Diffusion Method

  • Syed Akif Uddin Federal Urdu University, Karachi, Pakistan
  • Dr Lubna Bashir Federal Urdu University, Karachi, Pakistan
  • Dr Shazia Naz Federal Urdu University, Karachi, Pakistan
  • Dr Humera Naz Reign Pharmaceuticals Pvt. Ltd., Karachi, Pakistan
  • Saima Yasin Baig Federal Urdu University, Karachi, Pakistan
Keywords: Staphylococcus aureus, Escherichia coli, linezolid, disc diffusion, oxazolidinone

Abstract

Objective: The objective of this study was to evaluate the effectiveness of Linezolid on Staphylococcus aureus and Escherichia coli through disc diffusion method.

Methods: Discs of Linezolid were used for the evaluation of antibacterial activity of the Linezolid. Antibacterial activity was investigated against gram positive Staphylococcus aureus and gram negative Escherichia coli. The disc content of Linezolid was composed of 30 µg.

Results: The antimicrobial susceptibility test demonstrated that Linezolid was effective against Staphylococcus aureus and Escherichia coli. Two isolates of Staphylococcus aureus showed susceptibility (zones were found 26mm and 22mm), while one of the isolates of Escherichia coli showed susceptibility and the other showed resistance (zones were found 21mm and 18mm, respectively).

Conclusion: It is concluded that Linezolid have better antibacterial activity on Staphylococcus aureus as well as on Escherichia coli so can be used in treatment of different infections.

Author Biographies

Syed Akif Uddin, Federal Urdu University, Karachi, Pakistan

Department of Pharmaceutics, 

Dr Lubna Bashir, Federal Urdu University, Karachi, Pakistan

Department of Pharmaceutics, 

Dr Shazia Naz, Federal Urdu University, Karachi, Pakistan

Department of Pharmaceutics, 

Dr Humera Naz, Reign Pharmaceuticals Pvt. Ltd., Karachi, Pakistan

Quality Assuarnce Manager

Saima Yasin Baig, Federal Urdu University, Karachi, Pakistan

Department of Pharmaceutical Chemistry, 

Published
2018-12-31