Determination of the Anxiolytic Potential of New Polyhedral Formulation
Objective: The present study was aimed at investigating preclinical efficacy and toxicity of Anti-anxiety product. The different herbs have been used both traditionally and contemporaneously as anxiolytics. The polyherbal Anti-anxiety product consisting of Evolvulus alsinoides (Ariel part), Lavandula stoechas (flowers), Melissa officinalis (whole plant), Rauwolfia serpentine (roots) and Valeriana officinalis (roots) has been developed.
Results: The preclinical study on toxicity on animal model generated data which were analyzed statistically. The different tests were performed such as acute toxicity, elevated pulse maze, open field test, light-dark box test, locomotor activity. The results so obtained with polyherbal anti-anxiolytic drugs exhibited no toxicity and found to possess anxiolytic properties.
Conclusion: It was concluded that Polyherbal formulation has exhibited anti anxiolytic activity comparable to Diazepam.