Recommended Guidelines and Efficacy of Statins in Case of Hyperlipidemia

Rabia Zahid; Hafiz Muhammad Asif; Rida Tanveer; Zeeshan Summar; Misbah Najib

doi:10.37962/jpps.v9i4.516

Rabia Zahid Faculty of Medicine and Allied Health Sciences, The Islamia University, Bahawalpur, Pakistan.
Hafiz Muhammad Asif Faculty of Medicine and Allied Health Sciences, The Islamia University, Bahawalpur, Pakistan.
Rida Tanveer Faculty of Medicine and Allied Health Sciences, The Islamia University, Bahawalpur, Pakistan.
Zeeshan Summar Department of Pharmacy, University of Poonch Rawalakot Azad Kashmir, Pakistan
Misbah Najib Department of Pharmacy, The University of Peshawar, Pakistan.

DOI: https://doi.org/10.37962/jpps.v9i4.516

Keywords: Arteriosclerotic cardiovascular disease, cardiovascular diseases, β-Hydroxy β–methylglutaryl CoA

Abstract

Background: Hyperlipidemia is manifested by increased lipids and lipoprotein. Elevated lipid levels in blood are attributed due to having sedentary lifestyle and environmental conditions. Hyperlipidemia is one of the contributing risk factor for cardio vascular diseases. Human health is remarkably compromised because of cardio vascular disorders and complications associated with it. Statins are the frequently prescribed drug for the management of hyperlipidemia.

Objectives: The main objective of the proposed investigation was to study the prescribing patterns of statins. Moreover, the outcome of statins on lipid profile in hyperlipidemia patients had also been evaluated.

Method: A retrospective study was designed where patient data was obtained from the different hospitals of the twin cities i.e. Islamabad and Rawalpindi namely RIC, CDA and PIMS. Samples were obtained by random sampling technique. A sample of 50 patients was obtained. Low density lipoproteins (LDL), high density lipoproteins (HDL), triglycerides (TG) and total cholesterol (TC) were evaluated for the study.

Result: We calculated results of 3 months statins therapy in reducing LDL, TG, TC levels and elevating HDL levels. Our results were comparable with the NICE guidelines.