The Expression of NDRG1, VEGF and Ki-67 in Condyloma Acuminatum

Abstract

Objective: To explore the expression and significance of NDRG1, VEGF and Ki-67 in lesions of CA (Condyloma Acuminatum). Methods: SP immuno histochemistry method was used to measure the expression of NDRG1, VEGF and Ki-67 in 48 cases of CA and 18 normal skin controls. Results: The positive rates of NDRG1, VEGF and Ki-67 were 63. 83.33% (40/48), 93.75% (45/48) and 85.42% (41/48) in CA tissues, meanwhile 27.78% (5/18), 94.44% (17/18) and 61.11% (11/18) in the controls. The intensity of expression of NDRG1, VEGF and Ki-67 in CA tissues was obviously higher (++ ~ +++) than that in normal controls (- ~ ++). There was a significant difference both in the positive rates and the expression intensity of NDRG1, VEGF and Ki-67 between the two groups (P <0.05). The Spearman rank correlation analysis showed that, the expression of NDRG1 protein and VEGF protein were positively correlated by the Spearman rank correlation analysis (r = 0.346, P=0.016). Conclusion: The higher expression of NDRG1 and VEGF in CA tissues, they influenced both the occurrence and development of CA together.