Stability Evaluation of Intravenous Admixtures of Tramadol Hydrochloride and Acetaminophen at Different Storage Conditions

  • Kalsoom Naz Faculty of Pharmacy, The University of Lahore, Lahore Pakistan
  • Syed Saeed ul Hassan Katas College of Pharmacy, Lahore, Pakistan.
  • Muhammad Abbas Mukabbir College of Pharmacy, Bhimber Road, Gujrat Pakistan
  • Hammad Ahmed Imran Idrees College of Pharmacy, Sialkot, Pakistan
  • Muhammad Khalil ur Rehman College of Pharmacy, Universit yof the Punjab, Lahore, Pakistan
Keywords: Tramadol HCl, Acetaminophen, admixtures, simultaneous equation, analgesia.


Objective: This study is particularly performed to analyze the stability, whether an admixture containing ready-to-use solution of Tramadol HCl and Acetaminophen will be stable and compatible for a specified time. As intravenous admixture of Tramadol hydrochloride and Acetaminophen is normally used in hospitals for managing postoperative pains. Therefore, compatibility and stability of these admixtures need to be evaluated experimentally.

Methodology: Five different intravenous fluids were selected for the preparation of admixtures of these two drugs and studied at 5˚C and room temperature (20 – 25˚C) for one week time. Admixtures were evaluated visually for color change, turbidity, precipitation and fluctuation of pH at day 0,1,3,5 and 7. By employing UV/Visible spectrophotometer, percentage purity of both drugs was determined in admixture by applying Simultaneous Equation.

Results: All admixtures were found to retain their physical and chemical characteristics during the definite period of study. Furthermore, strengths of both drugs were persisted more than 90%. Therefore, admixtures of Tramadol HCl and Acetaminophen in various intravenous fluids were found to be stable and compatible when stored for 07 days at 25˚C and at 5˚C.

Conclusion: From the significant results of our work, it is suggested that ready to use of the admixture of Tramadol and Acetaminophen could be prepared and stored in advance for efficient and effective management of pain in busiest pharmacies and hospitals.