RADS Journal of Pharmacy and Pharmaceutical Sciences https://jpps.juw.edu.pk/index.php/jpps <p>RADS Journal of Pharmacy and Pharmaceutical Sciences (JPPS) is a quarterly peer-reviewed open-access Journal encourages you to publish original Research Articles, Review Articles, and Mini-Reviews, Short Communications and Case Reports in the field of Pharmaceutical, Health Sciences, Bio-medical Sciences, Allied sciences and the related fields for publications. The main Objective of the JPPS Journal is to provide a platform to publish novel findings on various scientific issues pertinent to Pharmacy, Pharmaceutical Sciences, Phyto-Pharmaceutical Sciences, Health and Bio-medical sciences.</p> en-US <p><a href="http://creativecommons.org/licenses/by-nc/4.0/" rel="license"><img style="border-width: 0;" src="https://i.creativecommons.org/l/by-nc/4.0/88x31.png" alt="Creative Commons License"></a><br> This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</p> jpps@juw.edu.pk (Chief Editor) jpps@juw.edu.pk (for technical support) Thu, 30 Dec 2021 00:00:00 +0000 OJS http://blogs.law.harvard.edu/tech/rss 60 Level of Knowledge and Attitude of Undergraduate Students of University of Peshawar about HIV/AIDS and its Patients https://jpps.juw.edu.pk/index.php/jpps/article/view/541 <p><strong><em>Background:</em></strong> HIV/AIDS is one of the alarming health conditions. HIV virus attack is cureless. It completely destroys human immune system in a slow progressive manner and makes body vulnerable to other diseases.</p> <p><strong><em>Objectives:</em></strong> To evaluate the level of knowledge and attitude of undergraduate students belonging to University of Peshawar. The aim of the study was to bring the attention of students towards HIV/AIDS care and prevention.</p> <p><strong><em>Methodology:</em></strong> Cross sectional study was designed where data was collected from the students enrolled in different departments; Pharmacy, Law, Business Administration, Journalism and Political Science on a carefully designed proforma. Students were asked to fill the questionnaires composed of two sections; knowledge of students about HIV/AIDS and attitude of students regarding management of HIV/AIDS patients if any, in daily routine life. Finally results were extracted from the collected information.</p> <p><strong><em>Results:</em></strong> 62.96% of undergraduate students of University of Peshawar had proper knowledge about AIDS spread, care and prevention while, 8.32% of students shared enough information about the management of HIV/AIDS patients in routine life. It was concluded that 37.04% students were ignorant about HIV/AIDS, while 41.68% showed lack of enough knowledge about how to manage to tackle HIV patients in routine life.</p> <p><strong><em>Conclusion:</em></strong> There is significant lacking of awareness about HIV/AIDS among students. There is a dire need to aware the population about this deadly disease to avoid its spread.</p> Muhammad Hasnain, Asif jan, Shahzar Khan, Shandana Begum, Bilal Muhammad, Shahid Alam, Shandana Khan Zeerak ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 https://jpps.juw.edu.pk/index.php/jpps/article/view/541 Thu, 30 Dec 2021 06:19:39 +0000 Comparison of Efficacy of Oral Nifedipine Versus Intravenous Labetalol in the Acute Management of Hypertensive Urgency of Pregnancy https://jpps.juw.edu.pk/index.php/jpps/article/view/538 <p><strong><em>Objective:</em></strong> <em>To compare the oral nifedipine efficacy with intravenous labetalol in hypertensiveurgency of pregnancy</em>.</p> <p><strong><em>Materials and methods:</em></strong> A total of 220 patients with sudden arterial hypertension who were 18 to 38 years old and had singleton gestations over 24 weeks were enrolled in this study. Patients with multiple pregnancies, heart disease, asthma, last child birth&gt;4 years old, and those allergic to nifedipine orlabetalol were excluded. The selected patients were randomly divided into two groups by balloting: Group A (oral nifedipine) and Group B (intravenous labetalol). For positive or negative results, variable results (efficacy) such as blood pressure control were observed within two hours of starting treatment.</p> <p><strong><em>Results:</em></strong> The mean age of women in group A was 24.24 ± 3.38 and in group B was 23.18 ± 4.05 years (p&lt;0.0001). The mean gestational age in group A was 34.75 ± 3.11 weeks and in group B was 33.98 ± 3.87 weeks (p&lt;0.0015). There was normalization of blood pressure within two hours in 93 (84.55%) patients in Group A while in Group B, it was seen in 77 (70.0%) patients. So, efficacy was 84.55% in group A (oral nifedipine) and 70.0% in group B (IV Labetalol) with p-value of 0.0003. The mean time for blood pressure control was 26.87 ± 9.22 and 45.54 ± 16.91 for oral nifedipine and IV labetalol group respectively with a p-value &lt;0.0001.</p> <p><strong><em>Conclusion:</em></strong> Oral nifedipine can be used as a first-line antihypertensive drug for the emergency treatment of hypertensive urgency of pregnancy.</p> <p><strong>Keywords:</strong> <em>Pregnancy-induced hypertension, blood pressure control, oral nifedipine, intravenous labetalol.</em></p> Sana Ujala, Ammad Masood, Lasania Mushtaq ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 https://jpps.juw.edu.pk/index.php/jpps/article/view/538 Thu, 30 Dec 2021 06:25:15 +0000 Pre-and Post-Operative Anxiety and Depression Levels in Orthopedic Surgery https://jpps.juw.edu.pk/index.php/jpps/article/view/441 <p><strong><em>Background:</em></strong> Anxiety and depression are the undesired psychological problems, directly associated with patients suffering from orthopedic trauma and underwent for orthopedic surgery.</p> <p><strong><em>Objectives:</em></strong> The objective of study was to determine the pre-and post-operative anxiety and depression levels in patients of orthopedic trauma.</p> <p><strong><em>Methodology:</em></strong> A descriptive observational study was conducted on 55 patients suffering from orthopedic trauma, selected by consecutive sampling technique from orthopedic department during October 2018 to December 2018. Patients were evaluated for anxiety and depression by using hospital anxiety and depression scale (HADS).</p> <p><strong><em>Results:</em></strong> Out of 55 patients suffering from orthopedic trauma, 63.6% were male and 36.4% were female with mean age of 44.93 ± 18.74. 44.5% were suffering from orthopedic trauma due to road accidents, and 43.6% due to ground fall. HADS level of anxiety and depression was 3.56, and 5.16 before surgery in orthopedic patients that increased significantly to 4.31, and 5.75 after surgery. Prevalence of anxiety and depression was 12.7%, and 18.2% in orthopedic patients before surgery that increased to 16.4%, and 23.6% after surgery respectively.</p> <p><strong><em>Conclusion:</em></strong> It was concluded that level of anxiety and depression was low in orthopedic trauma patients before surgery that increased after surgery, whereas gender, age, and poverty are directly associated with anxiety and depression.</p> Raza Askari, Asad Ali Kerawala, Muhammad Hassaan Khan, Nusrat Rasheed, Malik Amna Khatoon ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 https://jpps.juw.edu.pk/index.php/jpps/article/view/441 Thu, 30 Dec 2021 06:30:49 +0000 Estimation of Physicochemical Properties and Antioxidant Activity of Root Extract of Physalis minima https://jpps.juw.edu.pk/index.php/jpps/article/view/509 <p><strong><em>Background:</em></strong> <em>Physalis minima</em> is used in a variety of ailments. Although, there have been a few studies on the leaves and fruits of the <em>Physalis minima</em>, there have been relatively few investigations on the roots.</p> <p><strong><em>Objectives:</em></strong> The objective of the present study is to investigate the physicochemical parameters, trace elements, FTIR, and antioxidant activity of<em> Physalis minima</em> root extracts.</p> <p><strong><em>Methodology:</em></strong> Standard procedures were used to conduct these studies on n-Hexane, chloroform, and methanolic extracts of roots. The antioxidant activity was performed by standard procedures as DPPH (2, 2-diphenyl-1-picrylhydrazyl), phosphomolybdenum method, FRAP (ferric reducing antioxidant power assay), and hydrogen peroxide scavenging activity.</p> <p><strong><em>Results:</em></strong> Phytochemical analysis showed moisture content as 4.93±0.98%, total ash 10.09±0.76%, sulfated ash 4.92±0.91%, acid insoluble ash 4.3±0.88%, water-soluble extractive value 4.60 ± 0.01%, and alcohol soluble extractive value 17.92 ± 0.01%. FTIR analysis showed the presence of alkyl, amino, and tertiary alcohol groups. Percentage scavenging activity was measured by DPPH method and it was found that methanol extract showed maximum 93.525±0.276% scavenging activity as compared to chloroform 60.248±0.847%, and n-hexane 50.0±0.547%. Phosphomolybdenum assay showed maximum potential 86.81± 0.521% in the methanolic extract, 60.07±0.645% in chloroform extract, and 49.33±0.841% in n-hexane extract. FRAP showed maximum reducing value for methanol extract 86.153±0.203%, in chloroform 47.180±0.352%, and n-hexane extract 30.26±0.703%. By hydrogen peroxide assay, methanol extract possesses a maximum percentage of inhibition 91.71±0.992%, chloroform extract 60.64±0.721%, and for n-hexane was 51.32±1.664%.</p> <p><strong><em>Conclusion:</em></strong> <em>Physalis minima</em> root extract can be utilized to treat a variety of ailments and malignancies.</p> Muhammad Imran, Mussarat Rafiq, Syeda Eisha Hamid, Zaman Gul, Hafiza Nabeela Amaan, Muhammad Babar Khawar ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 https://jpps.juw.edu.pk/index.php/jpps/article/view/509 Thu, 30 Dec 2021 06:37:21 +0000 Fagonia Arabica Linn, a Miraculous Medicinal Plant with Diminutive Scientific Data but Hefty Potential https://jpps.juw.edu.pk/index.php/jpps/article/view/455 <p><strong><em>Background:</em></strong> <em>Fagonia arabica</em> is a highly potential medicinal plant whose dried aerial parts are used in folk medicine for a number of diseases as reported in historical monographs. This review article covers the phytoconstituents and scientifically proven pharmacological activities of different parts of the plant.</p> <p><strong><em>Methodology:</em></strong> A thorough searching of scientific literature was conducted utilizing important sites like Researchgate, GoogleScholar, PubMed, WoS etc. using the key words Fagonia, <em>Fagonia arabica</em> and phytoconstituents, medicinal uses, pharmacological activities, traditional uses in combination with Fagonia.</p> <p><strong><em>Results:</em></strong> The phytoconstituents explored and reported up to now in <em>Fagonia arabica</em> include Glycosides, Flavonoids, Triterpenes, Saponins and Sulfur compounds. It was found that plant possesses highly significant bioactive compounds and pharmacological activities. The <em>F. arabica</em> extract also work as green corrosion inhibitor for the Cu thus supports environment safety.</p> <p><strong><em>Conclusion:</em></strong> Concluding shortly, Genus <em>Fagonia</em> possesses variety of species containing medicinally important phytoconstituents and pharmacological activities but a little research work is carried out on <em>Fagonia arabica</em> proving scientifically the traditional use of the herb. So the species offer a lot for future researchers.</p> Iqra Kanwal, Nudrat Fatima, Asma Wazir, Mehwish Khan, Mehreen Zaheer, Darakhshan Masroor, Shazia Syed ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 https://jpps.juw.edu.pk/index.php/jpps/article/view/455 Thu, 30 Dec 2021 06:44:33 +0000 A review on Brain Cancer Mutations, Available Therapies, Existing Clinical Trials, and Forthcoming Brain Cancer Treatment https://jpps.juw.edu.pk/index.php/jpps/article/view/542 <p><strong><em>Aim:</em></strong> This paper aims at reviewing brain cancers, types of brain cancers, and mutations.</p> <p><strong><em>Methodology:</em></strong><strong> M</strong>ultiple electronic databases were searched such as Google Scholar, PubMed, HEC digital library, Elsevier, Research Gate, and Springer for all articles published in both local and international Journals for this review. Only articles written in English language were reviewed.</p> <p><strong><em>Mutation:</em></strong> The nature of the genetic mutations that induce brain cancers, as well as previously identified medicines to treat them, such as chemotherapy, steroids, and targeted therapies, have failed to explain further study and development of various drugs still in clinical trials.</p> <p><strong><em>Current Therapy:</em></strong> Temozolomide, the combined dose of Carboplatin, Melphalan, Etoposide Phosphate, Mannitol and Sodium Thiosulfate, combined therapy of Selumetinib, Dabrafenib, and Trametinib and the use of Palbociclib in chemotherapy are therapies and drugs under clinical trials aimed at replacing the traditional methods of brain cancer management therapies.</p> <p><strong><em>Conclusion:</em></strong> This review focuses on the currently available therapies for the different types of brain cancers, available clinical trial drugs for cancer, and the future of the treatment of brain cancer. Current research on brain cancer treatment is focused on delivering therapies across the blood-brain barrier to targeted mutated brain cells.</p> Sarmad Sheraz Jadoon, Tanzeel Ahmed ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 https://jpps.juw.edu.pk/index.php/jpps/article/view/542 Thu, 30 Dec 2021 06:48:03 +0000 Pharmacists Compensation and Job Satisfaction – A Cross Sectional Survey https://jpps.juw.edu.pk/index.php/jpps/article/view/569 <p><strong><em>Background &amp; Objective:</em></strong> Pakistan is a developing country i.e. why in most of the sector’s compensation packages are not equivalent to international market, which sometimes result in demotivation and dissatisfaction of employee. Due to this reason the main objective of current study was to investigate Pharmacist Compensation package and level of job Satisfaction.</p> <p><strong><em>Methodology:</em></strong> A cross-sectional study was conducted in Karachi from January 2021 to April 2021. Data has been collected from 301 Pharmacists by designed questionnaire. Ethical Review Committee, Faculty of Pharmacy, Hamdard University approved the study (Reference No. UERC-2021-004). Informed consent was obtained from each participant. Collected data was analyzed by Statistical Package for Social Sciences version 22 software.</p> <p><strong><em>Results:</em></strong> Among 301 respondents; Male 160(53.15%), Female 141(46.8%), Employed 280(93.02%), Unemployed 21(07%). Job sector; Private 247(82.05%), NGOs 30(10%), Government 15(4.98%). Role as a Pharmacist; Hospital-Pharmacists 78(26%), Production-Pharmacists 51(17%), QC/QA-Pharmacists 23(7.64%), Regulatory-Pharmacists 19(6.31%), Marketing &amp; Sales 36(12%), Academia 40(13.28%), Community-Pharmacists 54(18%). Payscale range (Pak. Rupees); 18000.00-35000.00 of 121(40.19%), 36000.00-55000.00 of 84(28%), 56000.00-100,000.00 of 50(16.61%), 101,000.00-200,000.00 of 24(8%) Pharmacists. Satisfied with salary; No 173(57.4%), Yes 86(28.5%). Compensation rating; Unfair 100(33.22%), Fair 142(47.17%), Good 54(17.94%), Excellent 5(1.66%). Salary enough for expenditures; No 184(61.12%), Yes 69(23%). Satisfaction-level; Extremely-unsatisfied 13(4.31%), Unsatisfied 47(15.61%), Fairly-satisfied 97(32.22%), Satisfied 104(34.55%), Absolutely-satisfied 32(10.63%). Promotion criteria; Fair 85(28.23%), Unfair 139(46.17%).</p> <p><strong><em>Conclusion:</em></strong> Pharmacist’s compensation in Pakistan is not as per qualification. Despite low compensation packages majority of Pharmacists are satisfied with their job.</p> Sheikh Abdul Khaliq, Arsham Zehra Maqsood, M. Ghias Uddin Siddiqui ##submission.copyrightStatement## http://creativecommons.org/licenses/by-nc/4.0 https://jpps.juw.edu.pk/index.php/jpps/article/view/569 Thu, 30 Dec 2021 06:52:31 +0000