Comparative Study of In-vitro Evaluation of Two Quinolone Derivatives by HPLC

  • Tanweer Alam Jinnah University for Women, Karachi Pakistan.
  • Asra Hameed Jinnah University for Women, Karachi Pakistan.
  • Farman Ali Drug Regulatory Authority of Pakistan, 4-B, SMCHS, Karachi – 74400, Pakistan
  • Kashif Maseed Drug Regulatory Authority of Pakistan, 4-B, SMCHS, Karachi – 74400, Pakistan
  • Neelam Sharif Jinnah University for Women, Karachi Pakistan.
  • Ghulam Sarwer Jinnah University for Women, Karachi Pakistan.
  • Khan Usmanghani Jinnah University for Women, Karachi Pakistan.

Abstract

Background: Quinolones are the antibacterial agents which vigorously inhibit the DNA synthesis. Pharmacodynamically they are DNA Gyrase inhibitor.


Objective: The aim of this study is to compare two quinolone derivatives using HPLC.


Result: The drug content is found to be as 96.25% in ofloxacin sample tablets and 99.64% in ciprofloxacin sample tablets when compared with standards.


Discussion The given method has found to be speedy, exact, defined, trustworthy and minimum time taking for the concurrent process of estimating ofofloxacin as well as ciprofloxacin drugs in the system of loose drug mockups, its preparations exhausting the supreme frequently engaged C-18 column through UV indicator.

Author Biographies

Tanweer Alam, Jinnah University for Women, Karachi Pakistan.

Department of Pharmacy

Asra Hameed, Jinnah University for Women, Karachi Pakistan.

Department of Pharmacy

Farman Ali, Drug Regulatory Authority of Pakistan, 4-B, SMCHS, Karachi – 74400, Pakistan

Central Drug Laboratory, 

Kashif Maseed, Drug Regulatory Authority of Pakistan, 4-B, SMCHS, Karachi – 74400, Pakistan

Central Drug Laboratory, 

Neelam Sharif, Jinnah University for Women, Karachi Pakistan.

Department of Pharmacy,

Ghulam Sarwer, Jinnah University for Women, Karachi Pakistan.

Department of Pharmacy

Khan Usmanghani, Jinnah University for Women, Karachi Pakistan.

Department of Pharmacy

Published
2017-07-07
How to Cite
ALAM, Tanweer et al. Comparative Study of In-vitro Evaluation of Two Quinolone Derivatives by HPLC. RADS Journal of Pharmacy and Pharmaceutical Sciences, [S.l.], v. 5, n. 2, p. 27-32, july 2017. ISSN 2521-8484. Available at: <http://jpps.juw.edu.pk/index.php/jpps/article/view/131>. Date accessed: 25 nov. 2017.