Comparative Study of In-vitro Evaluation of Two Quinolone Derivatives by HPLC
Background: Quinolones are the antibacterial agents which vigorously inhibit the DNA synthesis. Pharmacodynamically they are DNA Gyrase inhibitor.
Objective: The aim of this study is to compare two quinolone derivatives using HPLC.
Result: The drug content is found to be as 96.25% in ofloxacin sample tablets and 99.64% in ciprofloxacin sample tablets when compared with standards.
Discussion The given method has found to be speedy, exact, defined, trustworthy and minimum time taking for the concurrent process of estimating ofofloxacin as well as ciprofloxacin drugs in the system of loose drug mockups, its preparations exhausting the supreme frequently engaged C-18 column through UV indicator.