Clinical studies of linkus syrup for efficacy and safety for the treatment of cough, respiratory infection in children

  • Kashifa Khanum Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan
  • Aqib Zahoor Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan
  • Rabia Ali Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan
  • Khan Usmanghani Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan
  • Hina Rehman Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan
  • Muhammad Osama Alam Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan
  • Muhammad Daniyal Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan
  • Hira Munir Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan
  • Safila Naveed Jinnah University for Women, Karachi

Abstract

Background: Linkus syrup has been used to maintain healthy respiratory system and soothes throat, exert potent anti-tussive, expectorant and decongestant actions. Different clinical trials on Linkus have been conducted in hospitals to assess the efficacy and safety among adult and children.


Material and Methods: The size of the patients administered Linkus, in these studies are 80 in number. In some clinical trials conducted Linkus was naïve as the drug evaluated where as in others Linkus as test herbal drug was compared with allopathic drugs. Physical Examination: stethoscope observation for wheezing (a whistling or squeaky sound when you breathe) or other abnormal sounds.


Diagnostic Tests: exam of the mucus of nose or throat for bacterial infection.


Results:  In all children Linkus was given as a test and the (Mucaltin) control group, there was a significant improvement from the day before treatment to the day of treatment. However, the improvement was greater in the test (Linkus) groups for all the main outcome measures. Over all biochemical parameters of blood test dynamics in test and control groups on the background of Linkus syrup 90 ml administrations.


Conclusion: The participating physicians rated the Linkus products higher than the control drug for symptomatic relief of their children cough and overcome the difficulty due to upper respiratory tract infection (URI). Linkus may be a preferable treatment for cough and sleep difficulty associated with childhood URI.

Author Biographies

Kashifa Khanum, Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan

Research & Development Department, 

Aqib Zahoor, Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan

Research & Development Department,

Rabia Ali, Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan

Research & Development Department, 

Khan Usmanghani, Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan

Research & Development Department,

Hina Rehman, Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan

Research & Development Department,

Muhammad Osama Alam, Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan

Research & Development Department,

Muhammad Daniyal, Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan

Research & Development Department,

Hira Munir, Herbion Pakistan (Pvt.) Ltd., Karachi, Pakistan

Research & Development Department,

Safila Naveed, Jinnah University for Women, Karachi

Faculty of Pharmacy,

Published
2017-07-07
How to Cite
KHANUM, Kashifa et al. Clinical studies of linkus syrup for efficacy and safety for the treatment of cough, respiratory infection in children. RADS Journal of Pharmacy and Pharmaceutical Sciences, [S.l.], v. 5, n. 2, p. 36-43, july 2017. ISSN 2521-8484. Available at: <http://jpps.juw.edu.pk/index.php/jpps/article/view/133>. Date accessed: 25 nov. 2017.