Simple Spectrophotometric Assay of Available Brands of Acetaminophen Tablets and their Comparative Study
A rapid, simple, accurate, and economical acetaminophen spectrophotometric method has been developed and validated for the assay of and compare assay of brand available in the market. The analysis is based on the UV absorbance maxima at about 246 nm wavelength of acetaminophen using methanol as solvent. A sample of drug was dissolved in methanol to produce a solution containing acetaminophen. Similarly, a sample of ground tablets of different brand were extracted with methanol and diluted with the same methanol. The absorbance of sample preparation was measured at 246 nm against the solvent blank and the assay was determined by comparing with the absorbance of available brand. The method can be applied for the routine QC quantitation of acetaminophen in tablet formulation and active.