Study Of Antibacterial and Physicochemical Properties of Local and International Brands of Moxifloxacin Used in Clinical Patient Care in Pakistan
Objective: Moxifloxacin antibiotic belongs to fourth-generation fluoroquinolone class and used to treat various Gram-positive and Gram-negative bacterial. The present work designed to evaluate the pharmaceutical quality attributes and antibacterial activity of five different local and international brands of moxifloxacin 400mg tablets (B1-B5) available in Pakistan with different price ranges.
Methodology: Different physicochemical parameters including weight, thickness variation, disintegration time, chemical assay and in vitro dissolution evaluation were performed on above mentioned brands of moxifloxacin. Disk diffusion method (Bauer-Kirby susceptibility test) were also used to evaluate the in-vitro antibacterial activity of these brands on three standard bacterial culture of Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli by micro dilution minimum inhibitory concentration (MIC) assay technique and compared with their respective reference standard (A).
Results: All the brands was found to be similar according to compendial quality standards tested for physicochemical evaluation with more than 90% drug release in 0.1N HCl (pH 1.2). All brands exhibited good in vitro activity (zone of inhibition: 26 – 38 mm) against all the standard cultures in terms of clinical effectiveness despite of little variation in price.
Conclusion: It was concluded that a good pharmaceutical association was observed amongst all the local and international brands of moxifloaxcin and each product were also observed within a particular microbial limits exhibits satisfactory effectiveness required for the treatment of particular infectious disease conditions. This study also help medical practitioner to prescribe alternative antibiotic product to the patients in case of unavailability of the brand and for those who are unable to afford the costly treatment.
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