The Relationship Between the Expression of Tumor Associated Fibroblasts Cav-1 and MCT4 and the Prognosis of Papillary Carcinoma of Breast
Aim: To investigate the potential role of MCT4 in the progress of IMPC in CAFs. Methods: MCT4 and Cav-1 expression in 86 IMPC patients were detected by immunohistochemical LSAB methods and the 105 cases of non specific invasive ductal carcinoma (IDC-NOS) selected as the control. Compared the differences of the expressions of them in different issues and analysed the relationship of the main pathological features of the expression of Cav-1 and MCT4 in different ages, tumor stages and hisological grades. Results: The study conformed that the miss expression of Cav-1 on CAFs and the expression of MCT4 up-regulated were related on the poor prognosis of IMPC patients. Conclusion: It suggested that CAFs may be the target of the tumor and can supply the new basis for the treatment of breast cancer.