The Relationship Between the Expression of Tumor Associated Fibroblasts Cav-1 and MCT4 and the Prognosis of Papillary Carcinoma of Breast

  • Li Cui The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
  • Miaomiao Sun Henan Cancer Hospital, Zhengzhou city, PR China
  • Zhihua Zhao The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
  • Jianping Yang The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
  • Yupeng Zheng The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
  • Lulu He The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
  • Kuisheng Chen The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
  • Qingxia Fan The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China
Keywords: breast cancer, CAFs, Cav-1, MCT4

Abstract

Aim: To investigate the potential role of MCT4 in the progress of IMPC in CAFs. Methods: MCT4 and Cav-1 expression in 86 IMPC patients were detected by immunohistochemical LSAB methods and the 105 cases of non specific invasive ductal carcinoma (IDC-NOS) selected as the control. Compared the differences of the expressions of them in different issues and analysed the relationship of the main pathological features of the expression of Cav-1 and MCT4 in different ages, tumor stages and hisological grades. Results: The study conformed that the miss expression of Cav-1 on CAFs and the expression of MCT4 up-regulated were related on the poor prognosis of IMPC patients. Conclusion: It suggested that CAFs may be the target of the tumor and can supply the new basis for the treatment of breast cancer.

Author Biographies

Li Cui, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

Department of Pathology, 

Miaomiao Sun, Henan Cancer Hospital, Zhengzhou city, PR China

Department of Pathology

Zhihua Zhao, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

Department of Pathology, 

Jianping Yang, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

Department of Pathology, 

Yupeng Zheng, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

Department of Pathology, 

Lulu He, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

Department of Pathology, 

Kuisheng Chen, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

Department of Pathology, 

Qingxia Fan, The First Affiliated Hospital of Zhengzhou University, Zhengzhou city, PR China

Medical Oncology, 

Published
2016-01-17
Issue
Vol 4 No 1 (2016): Volume 4 (1) 2016
Section
Articles

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