In Vitro Anti-Ulcer Potential of Nardostachys jatamansi Through Anti-Urease Assay
Abstract
Background: Drug resistance is the reason for search of new medicines from natural sources. Natural products and plants showed gastro-protective and anti-ulcer effects by either prophylactic (antioxidant) or therapeutic means (anti-urease, etc.). Nardostachys jatamansi is used traditionally as gastro-protective. The study aims to evaluate anti-ulcer activity of the methanolic extract of N. jatamansi through its anti-urease potential and also appraise its antioxidant activity.
Methodology: Antioxidant activity was evaluated through DPPH radical scavenging assay. Elisa microplate reader was used to estimate DPPH and urease inhibition.
Results: The study results showed that N. jatamansi inhibited DPPH, and urease significantly (p≤ 0.05). IC50 of N. jatamansi against DPPH and urease were 218.5±1.0 µg/mL and 55.9±1.3 µg/mL, respectively.
Conclusion: This study suggests the anti-urease potential of N. jatamansi. So, N. jatamansi could be used in peptic ulcer treatment. Moreover, this study provides proof of its traditional gastro-protective use.
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