Pharmaceutical Equivalence Studies of Different Brands of Sparfloxacin 100 mg Tablets Available in Pakistani Market

Abstract

Objective: The comparative study has been designed to evaluate the quality and physicochemical characteristics of five different Sparfloxacin (100 mg) tablet brands.

Methods: A quality control assessment by different quality parameters and cost effective comparative pharmaceutical equivalence studies were conducted on five brands of Sparfloxacin 100 mg tablets. These brands were coded as S-1, S-2, S-3, S-4 and S-5 and their prices were 678.01, 325, 400, 300 and 199 rupees per pack, respectively. Statistical calculation (ANOVA) and similarity factor (f₂) were also applied to compare the results of different brands.

Results: Results of physical and chemical parameters of all brands were found satisfactory. Similarly, the value of f₂ showed that brand S-2 was found to be very similar with reference (S-1) while other brands also showed similarity.

Conclusion: This study would be helpful for the physicians and pharmacists for the selection of cost-effective and quality product for the treatment of variety of bacterial infections such as urinary tract infection, respiratory tract infection, ear infection and skin infections.