Role of Major Caspases in Neurodegenerative Diseases

  • Muhammad Liaquat Raza
  • Ayesha Khan
  • Hidayat Hussain
Keywords: Caspases, CNS disorder, neurodegeneration, taupathy, dopamine


Caspases, specially 1,3,6 are enzymes that involve in inflammatory process via cytokines and interleukin 1β. It engages in various diseases including neurodegenerative diseases. In this review we focused to review the role of caspase-1 mainly on CARD/DED molecular modulation system, TNF-α and pro IL-1β affiliated to neuronal cell death that occurs in the Alzheimer’s disease (AD), Parkinson’s disease (PD) and Huntington’s disease (HD).

Author Biographies

Muhammad Liaquat Raza

Department of Clinical Sciences, Epilepsy Center, Lund University, Lund, Sweden

Ayesha Khan

Department of Pharmacology, Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

Hidayat Hussain

Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Salle), Germany

Review Article