Novel Drug Delivery Approaches in Formulation Development; Stability Considerations and Quality Features of Herbal Products
Objective: Over the past few years a substantial modification in the drug delivery systems have been noticed which is expected to continue with even a greater velocity in future as well. This is because of the recent developments in the technological aspects and introduction of variety of drug delivery tools and devices in routine healthcare and research sectors. Such advancements have greatly influenced the herbal drug manufacturing technology at consistent pace as well.
Method: In this paper, various literature sources were reviewed for herbal formulations manufacturing methods that can be employed in more sophisticated and palatable forms with improved quality attributes and better effectiveness by using modern tools of dosage form designing. These products offer better physico-chemical features, less prone to degradation and reduced toxicity. Enhanced stability along with improved bioavailability potential are additional attributes. Drug stability may be regarded as the maintenance of product identity, therapeutic efficacy and strength within the adequate limit of specification throughout the shelf life.
Results: It was found that quality attribute is considered crucial for herbal moieties as they are composed of complex nature. The quality of herbal products changes greatly with time under the influence of environmental factors like humidity, temperature, light and oxygen. Range of these alterations may prove significant in altering herbal products’ profile in terms of particle size range of drug, microbial contamination and trace metal sources, leachable constituents and loss of therapeutic activity, etc.
Conclusion: Henceforth assessment of physical, chemical, therapeutic, microbiological and toxicological parameters can provide an important insight for herbal stability studies.
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