Effect of Cardioselective Beta Blocker on Lisinopril Treated Isolated Rabbit’s Heart
Abstract
Background: Certain drugs produce unpredictable responses when used in emergency conditions. These variable outcomes may be harmful or beneficial for the patient.
Objective: This study has been conducted to evaluate the pharmacodynamic interaction between angiotensin converting enzyme inhibitor and metoprolol, a selective blocker of β1 receptors. Cardioselective beta blockers are commonly used to treat hypertension, arrhythmias and ischemic heart disease.
Method: In this study, 20 healthy male rabbits were selected and divided into two groups. Effective dose of Lisinopril (10 mg/kg) was administered orally via oral feeding, for 9 days. By using Langendroff’s technique, the effects of metoprolol were observed in isolated hearts.
Result: The data showed that the effective dose of Lisinopril (10 mg/kg daily orally) increases the inotropic and chronotropic effects of metoprolol significantly (p<0.05).
Conclusion: Therefore, lisinopril, an inhibitor of angiotensin converting enzyme may increase the response of cardioselective beta blocker metoprolol in isolated rabbit’s heart.
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