Comparative Anti-Inflammatory and Analgesic Activities of Qurs-Saffron and Quknar Polyherbal Tablets in Mouse Model

  • Muhammad Shoaib Akhtar
  • Abdul Malik
  • Haroon Arshad
  • Nabiha Pervez
  • Nadeem Irshad
Keywords: Anti-inflammatory, analgesic, carrageenan, Qurs-Saffron, Quknar, Ibuprofen.

Abstract

Objective: We aimed to study the anti-inflammatory and analgesic effects for two polyherbal tablets in animal model.

Methods: Suspensions of Qurs-Saffron and Quknar polyherbal formulations (p.o.) were evaluated for their anti-inflammatory (in carrageenan-induced paw edema) and analgesic activities (in formalin-induced paw licking test) in albino mice using Ibuprofen (50 mg/kg, orally) as standard drug. Acute toxicity testing of suspensions from Qurs-Saffron and Quknar tablets was also performed at doses 1, 2 and 3 gm/kg, orally. Parametric data were evaluated by one way ANOVA followed by Tukey’s test while graphics were made using GraphPad Prism.

Results: Administration of Qurs-Saffron (1000, 1500, 2000 mg/kg) and Quknar (500, 750, 1000 mg/kg) suspensions showed significant (P < 0.05) inhibition of paw edema and at later time point (after 3 hours), both suspensions showed highly significant (P < 0.001) inhibition of paw edema. In another experiment (formalin-induced paw licking test), Qurs-Saffron (2000 mg/kg) and Quknar (1000 mg/kg) showed the highly significant (P < 0.001) analgesic activity.

Conclusion: Qurs-Saffron and Quknar tablets possessed anti-inflammatory and analgesic effects that were most likely due to flavonoids and phenolic compounds with free radical scavenging properties which significantly reduced inflammation and pain in treated mice and were also found safe in toxicity testing.

Author Biographies

Muhammad Shoaib Akhtar

Department of Pharmacology, College of Pharmacy, University of Sargodha, Sargodha-40100, Pakistan

Abdul Malik

Department of Pharmacology, College of Pharmacy, University of Sargodha, Sargodha-40100, Pakistan

Haroon Arshad

Health Department, Government of the Punjab, Lahore-54000, Pakistan

Nabiha Pervez

Department of Pharmacology, College of Pharmacy, University of Sargodha, Sargodha-40100, Pakistan

Nadeem Irshad

Department of Pharmacy, Quaid-e-Azam University, Islamabad-45320, Pakistan

Published
2020-01-30