Evaluation of Anti-Inflammatory and Analgesic Activities of Methanolic Extract of Aitchisonia Rosea in Albino Mice

  • Shahid Rasool College of Pharmacy, University of Sargodha, Sargodha-44100, Pakistan
  • Ambreen Malik Uttra College of Pharmacy, University of Sargodha, Sargodha-44100, Pakistan
  • Mehreen Malik Uttra DHQ Teaching Hospital Sargodha, Sargodha-44100, Pakistan
  • Faheem Ahmed Faculty of Pharmacy, University of Central Punjab, Lahore-54000, Pakistan
  • Khizar Abbas Faculty of Pharmacy, Bahaudin Zakaria University, Multan-66000, Pakistan
DOI: https://doi.org/10.37962/jpps.v8i1.371
Keywords: Aitchisonia rosea, analgesic, ibuprofen, anti-inflammatory

Abstract

Objective:  Current analysis aims at in-vivo investigation of analgesic and anti-inflammatory activities of Aitchisonia rosea methanolic extract.

Methods: Albino mice (20-30 g) were used in the study. Extract at 200, 400 and 800 mg/kg doses was tested against egg albumin and carrageenan induced mice paw edema along with formalin persuaded paw licking and acetic acid prompted writhing for analgesic activity.

Results: Results depicted dose reliant and significant (p<0.001) inhibition of carrageenan as well as egg albumin brought paw edema, abdominal constrictions/ hind limb stretching tempted by acetic acid and formalin instigated paw licking. Capability of crude extract to halt inflammatory and analgesic response was akin to that of ibuprofen in all models.

Conclusion: The current findings support the use of Aitchisonia rosea for inflammatory conditions, which might be attributed to its previously proven high alkaloid, flavonoids, phenol, tannins content and free radical scavenging activity.

Published
2020-09-04
Issue
Vol 8 No 1 (2020): Volume 8 (1) 2020
Section
Articles

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