Frequency of Thyrotoxicosis in Patient with One Sided Exophthalmos

  • Tahreem Zafar Mufti Mehmood Memorial Hospital, Dera Ismail Khan, Pakistan
  • Shumaila Perveen Faculty of Pharmacy, University of Sindh, Jamshoro, Pakistan
  • Nisar Khan GMC MTI, Dera Ismail Khan, Pakistan
  • Salman khan GMC MTI, Dera Ismail Khan, Pakistan
  • Tahseen Ahmed Institute of Pharmaceutical Sciences, PUMHS, Nawab Shah, Pakistan
Keywords: Proptosis, Thyrotoxicosis, Thyroid eye disease


Background: Thyroid associated Opthalmo-pathy is a condition of lid retraction causing a staring appearance. This occurs in any form of thyrotoxicosis as a result of sympathetic overactivity.Exophthalmos is the forward protrusion of eye ball beyond the orbital rim.

Material & Methods: This case series was observed in medical department Mufti Mehmood Teaching Hospital DIKhan, Pakistan over a period of eight months from February 2018 to September 2018. Detailed history with reference of duration of illness, mode of onset, progression and associated symptoms like fever, pain, diplopia and loss of vision was taken. Complete examination of orbit, eyelid, anterior and posterior segment was done. Routine Investigations along with special diagnostic tests like TFTs and MRI were performed to aid etiological diagnosis.

Results: A total 47 patients were observed during this study period. Out of these 20 (21.27%) were male and 27 (57.44%) were female with male to female ratio 1:1.35 with mean age of 32 years. Out of 47 patients30 (63.82%) patients were having thyrotoxicosis as a cause of exophthalmos, 10(21.27%) were having retrobulbartumour, 5(10.63%) patients were with cavernous sinus thrombosis and 2(4.25%) patients were having idiopathic cause of exophthalmos.

Conclusion: Thyrotoxicosis is the common cause of one sided exophthalmos and should be considered in all patients with one sided exophthalmos.