Determination of Factors Effecting Medication Adherence in Depressed Patients Receiving Antidepressants in Pakistan

  • Muhammad Amir Pharmacy Department, Lady Reading Hospital, Peshawar, Pakistan
  • Nathanial Rickles School of Pharmacy, University of Connecticut, USA
  • Zeeshan Feroz Basic Sciences Department, College of Science and Health Professions, King Saud bin Abdulaziz University for Health Sciences, Riyadh, Kingdom of Saudi Arabia
  • Anwer Ejaz Beg Faculty of Pharmacy, Ziauddin University, Karachi, Pakistan
Keywords: Medication adherence, Factors, Antidepressants, Karachi, Pakistan, Depression


Background: The prevalence of depression in Pakistan is considered to be higher than other developing countries. Medication adherence is a major factor in the success and cost effectiveness of the treatment of depression. Limited information relating medication adherence and its factor are available for patients in Pakistan.

Objective: The study aim to determine the factors associated with adherence of antidepressants in depressed patients.

Methods: The study was conducted in outpatient setting of hospital. 200 participants were enrolled in the study. Self-assessment tool was used to determine the medication adherence.

Results: The results showed that factors such as gender, education, employment and total number of medications have significant influence on adherence of antidepressants. The study also shows that the relationship of factors and adherence changes with the duration of therapy.

Conclusion: Factors play a vital role in understanding the barriers in medication non-adherence. Factors effecting medication adherence change with respect to the duration of therapy. Gender, employment, morbidity and number of medications taken earlier have significant influence on medication adherence of antidepressants in depressed patients.