Determination of the Anxiolytic Potential of New Polyhedral Formulation

Saira Bano; Hina Mahmood; Kashifa Khanum; Khan Usmanghani; Samina Afzal; Muhammad Daniyal

Saira Bano Department of Research and Development
Hina Mahmood Department of Research and Development
Kashifa Khanum 1Department of Research and Development
Khan Usmanghani 1Department of Research and Development
Samina Afzal Faculty of Pharmacy
Muhammad Daniyal Department of Medical Affairs and Training,

Keywords: Anxiolytic, polyherbal, Evolvulus alsinoids, Lavadula stoechas, Melissa officinalis, Rauwolfia serpentine and Valeriana officinalis

Abstract

Objective: The present study was aimed at investigating preclinical efficacy and toxicity of Anti-anxiety product. The different herbs have been used both traditionally and contemporaneously as anxiolytics. The polyherbal Anti-anxiety product consisting of Evolvulus alsinoides (Ariel part), Lavandula stoechas (flowers), Melissa officinalis (whole plant), Rauwolfia serpentine (roots) and Valeriana officinalis (roots) has been developed.
Results: The preclinical study on toxicity on animal model generated data which were analyzed statistically. The different tests were performed such as acute toxicity, elevated pulse maze, open field test, light-dark box test, locomotor activity. The results so obtained with polyherbal anti-anxiolytic drugs exhibited no toxicity and found to possess anxiolytic properties.
Conclusion: It was concluded that Polyherbal formulation has exhibited anti anxiolytic activity comparable to Diazepam.