Antitussive Effect of Aerial Parts of Caesalpinia Pulcherrima L. by Sulfur Dioxide Induced Cough in Rats

  • Syed Muhanmmad Umer Gilani university of Karachi
  • Rifat Roshan
  • Salman Ahmed
  • Muhammad Mohtasheem Hasan
Keywords: Caesalpinia pulcherrima L., Caesalpiniaceae, Antitussive.


Study objectives: The aim of the study was to evaluate antitussive effect of aerial parts of ethanolic extract of Caesalpinia pulcherrima (Caesalpiniaceae).

Methods: In this study cough was induced by the sulfur dioxide induction method. Four groups of animals were made with six animals in each group and all drugs were administered orally. Group I as control, group II as standard while groups III and IV received 200 and 400 mg/kg Caesalpinia pulcherrima aerial parts extract.

Results: Suppression of cough was observed by Caesalpinia pulcherrima aerial parts (CPAP) extract. Doses of 200 and 400 mg/kg Caesalpinia pulcherrima aerial parts extract showed highly significant results compared to standard at 60 and 90 min of drug administration.

Conclusion: From the above results it can be concluded that plant have significant activity of cough suppresstion.