Epidemiological and Pathophysiological Review of Helicobacter pylori

  • Jibran Sualeh Muhammad Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
  • Syed Faisal Zaidi College of Medicine, King Saud bin Abdulaziz University of Health
  • Khan Usmanghani Jinnah University for Women, Karachi
Keywords: Helicobacter pylori, Epidemiology, Transmission, Pathophysiology, Inflammation

Abstract

Helicobacter pylori infection induces chronic gastritis, peptic ulcer disease, gastric cancer and a number of extragastric related morbidities. Hence, it is now recognized as a worldwide problem. Although clinical outcomes are dependent upon bacterial prevalence, virulence factors, host genetic diversity and environment, focus of this review is on recent findings relevant to epidemiology and gastric pathophysiology of H. pylori infection. This article presents a review of the published literature mainly from last 15 years. The topics of main concerns were bacterial epidemiology, virulent factors and the inflammatory response of H. pylori infection. The authors used MeSH terms “Helicobacter” with “pathophysiology,” “pathogenesis,” or “gastric inflammation” to search PubMed database. All relevant studies identified were included and are described according to the aforementioned subheadings.

Author Biographies

Jibran Sualeh Muhammad, Sciences, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

Department of Gastroenterology and Hematology, Graduate School of Medicine and Pharmaceutical

Syed Faisal Zaidi, College of Medicine, King Saud bin Abdulaziz University of Health

Department of Basic Medical Sciences,

Khan Usmanghani, Jinnah University for Women, Karachi

Clinical Pharmacy and Health Care, Faculty of Pharmacy,

Published
2014-04-21