Development and Clinical Evaluation of Polyherbal Laxative Laxisen
Constipation being one of the most common and frequently occurring symptoms of gastrointestinal disorders is high in prevalence rate, causing economic burden and badly effecting quality of life. Multiple research studies have been carried out to clinically evaluate, assess and address the treatment for both acute and chronic constipation in adults. However limited evidences are available for the efficacy of available treatment options for the management of constipation. This study is a prospective, open labeled, uni-center and observational clinical trial and was carried out at out-patient department of clinical medicine at Jinnah Medical Center, Korangi, Karachi, Pakistan to evaluate the clinical efficacy and safety of polyherbal formulation Laxisen in 35 patients with complaints of constipation.. The study drug was administered for 1- 2 weeks for acute and 1-6 weeks for chronic constipation patients. After following up patients for specified time period complete remission of constipation was observed and the drug was found significantly effective (p < 0.003). The mean weekly frequency of bowl movements was 9.95 for acute constipation while 9.23 for chronic constipation. Significant increase in frequency of the bowl movements was observed for all patients.