Comparative Analysis of Different Brands of Metformin and Sitagliptin Combination

Abstract

Objective: To compare different brands of metformin and sitagliptin combinations and check that whether the brands meet the standard criteria mentioned in monographs.

Methods: Five different brands of metformin and sitagliptin combination were purchased from the local market and evaluated for their bioequivalence studies. The brands were checked for different physicochemical tests like hardness, thickness, disintegration, and dissolution. The results were observed and concluded for their bioequivalence studies

Results: The results showed that all brands have weights ranging from 600-900mg per tablet. Brand 1 has a higher weight as compared to other brands, whereas, Brand 2 and 5 have almost very closer weights, similarly Brand 3 and 4 weights are very close to each other. All the brands had a hardness of less than 4 kg which is within an acceptable limit for conventional tablets. The friability test showed that all the brands lie under the limit which is NMT 1%. The disintegration time of film-coated tablets of each brand was found to be within the range of 2-13 minutes. While the dissolution test of all brands meet the standard (NLT 85%) release within 30 minutes except brand 3.

Conclusion: Comparative analysis of different brands of Metformin and Sitagliptin concluded that all brands except brand 3 meet the standard criteria for conventional tablets.