The Relationship Between the Expression of B7-H1/PD-1+in Breast Cancer and Micro-environment TILs and the Prognosis and the Molecular Typing
Abstract
AimTo analyze the differences of the distribution patterns and the density of immune cells in the different parts of the breast cancer tissues, and to evaluate the relationship between the expression of the immunosuppressive molecule B7-H1 and the infiltration of cell Foxp3+Treg, thereby to investigate the prognostic significance for the breast cancer patients, therefore to screen out the immune cells and immune factors which possess prognostic significance in order to provide new theoretical bases for individual immunological therapy for breast cancer. MethodThe immunohistochemical methods were separately applied to study those breast cancer patients of two groups who had never been implemented any anti-cancer treatments after the prognosis and before the operation. Result Proved by many factors, the expression of tumor cell B7-H1 could be used as the independent predictive index of disease-free survival and overall survival for the patients. Conclusion The tumor cell B7-H1 is expected to be a target for the immunotherapy of breast cancer, and to provide a new theoretical basis for the immunotherapy of breast cancer.
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